Ontology highlight
ABSTRACT:
SUBMITTER: Perona-Wright G
PROVIDER: S-EPMC2895995 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Perona-Wright Georgia G Mohrs Katja K Mohrs Markus M
Nature immunology 20100425 6
Cytokines are soluble proteins that regulate immune responses. The present paradigm is that cytokine production in lymphoid tissues is tightly localized and signaling occurs between conjugate cells. Here we assess cytokine signaling during infection by measuring in vivo phosphorylation of intracellular signal transducer and activator of transcription (STAT) proteins. We show that interferon-gamma (IFN-gamma) and interleukin 4 (IL-4) signaled to the majority of lymphocytes throughout the reactive ...[more]