Ontology highlight
ABSTRACT:
SUBMITTER: Uaesoontrachoon K
PROVIDER: S-EPMC3529351 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Uaesoontrachoon Kitipong K Wasgewatte Wijesinghe Dimuthu K DK Mackie Eleanor J EJ Pagel Charles N CN
Disease models & mechanisms 20120823 1
Osteopontin is secreted by skeletal muscle myoblasts and stimulates their proliferation. Expression of osteopontin in skeletal muscle is upregulated in pathological conditions including Duchenne muscular dystrophy, and recent evidence suggests that osteopontin might influence the course of this disease. The current study was undertaken to determine whether osteopontin regulates skeletal muscle regeneration. A whole muscle autografting model of regeneration in osteopontin-null and wild-type mice ...[more]