Ontology highlight
ABSTRACT:
SUBMITTER: Taudien S
PROVIDER: S-EPMC3532138 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Taudien Stefan S Gäbel Gabor G Kuss Oliver O Groth Marco M Grützmann Robert R Huse Klaus K Kluttig Alexander A Wolf Andreas A Nothnagel Michael M Rosenstiel Philip P Greiser Karin Halina KH Werdan Karl K Krawczak Michael M Pilarsky Christian C Platzer Matthias M
BMC research notes 20121113
<h4>Background</h4>Human ß-defensins are a family of antimicrobial peptides located at the mucosal surface. Both sequence multi-site variations (MSV) and copy-number variants (CNV) of the defensin-encoding genes are associated with increased risk for various diseases, including cancer and inflammatory conditions such as psoriasis and acute pancreatitis. In a case-control study, we investigated the association between MSV in DEFB104 as well as defensin gene (DEF) cluster copy number (CN), and pan ...[more]