Ontology highlight
ABSTRACT:
SUBMITTER: Alonzo F
PROVIDER: S-EPMC3536884 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Alonzo Francis F Kozhaya Lina L Rawlings Stephen A SA Reyes-Robles Tamara T DuMont Ashley L AL Myszka David G DG Landau Nathaniel R NR Unutmaz Derya D Torres Victor J VJ
Nature 20121212 7430
Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore-forming bi-component leukotoxins that are toxic towards neutrophils, but also specifically target other immune cells. Despite decades since the first description of staphylococcal leukocidal activity, the host factors responsible for the selectivity of leukotoxins towards different immune cells remain unknown. Here we iden ...[more]