Ontology highlight
ABSTRACT:
SUBMITTER: Alonzo F
PROVIDER: S-EPMC3258504 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Alonzo Francis F Benson Meredith A MA Chen John J Novick Richard P RP Shopsin Bo B Torres Victor J VJ
Molecular microbiology 20111220 2
Bloodstream infection with Staphylococcus aureus is common and can be fatal. However, virulence factors that contribute to lethality in S. aureus bloodstream infection are poorly defined. We discovered that LukED, a commonly overlooked leucotoxin, is critical for S. aureus bloodstream infection in mice. We also determined that LukED promotes S. aureus replication in vivo by directly killing phagocytes recruited to sites of haematogenously seeded tissue. Furthermore, we established that murine ne ...[more]