Ontology highlight
ABSTRACT:
SUBMITTER: Ziarek JJ
PROVIDER: S-EPMC3537072 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Ziarek Joshua J JJ Veldkamp Christopher T CT Zhang Fuming F Murray Nathan J NJ Kartz Gabriella A GA Liang Xinle X Su Jidong J Baker John E JE Linhardt Robert J RJ Volkman Brian F BF
The Journal of biological chemistry 20121112 1
The ability to interact with cell surface glycosaminoglycans (GAGs) is essential to the cell migration properties of chemokines, but association with soluble GAGs induces the oligomerization of most chemokines including CXCL12. Monomeric CXCL12, but not dimeric CXCL12, is cardioprotective in a number of experimental models of cardiac ischemia. We found that co-administration of heparin, a common treatment for myocardial infarction, abrogated the protective effect of CXCL12 in an ex vivo rat hear ...[more]