Ontology highlight
ABSTRACT:
SUBMITTER: Panigrahi S
PROVIDER: S-EPMC3537845 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Panigrahi Soumya S Ma Yi Y Hong Li L Gao Detao D West Xiaoxia Z XZ Salomon Robert G RG Byzova Tatiana V TV Podrez Eugene A EA
Circulation research 20121015 1
<h4>Rationale</h4>A prothrombotic state and increased platelet reactivity are common in pathophysiological conditions associated with oxidative stress and infections. Such conditions are associated with an appearance of altered-self ligands in circulation that can be recognized by Toll-like receptors (TLRs). Platelets express a number of TLRs, including TLR9; however, the role of TLR in platelet function and thrombosis is poorly understood.<h4>Objective</h4>To investigate the biological activiti ...[more]