Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC4862743 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhu Weifei W Gregory Jill C JC Org Elin E Org Elin E Buffa Jennifer A JA Gupta Nilaksh N Wang Zeneng Z Li Lin L Fu Xiaoming X Wu Yuping Y Mehrabian Margarete M Sartor R Balfour RB McIntyre Thomas M TM Silverstein Roy L RL Tang W H Wilson WHW DiDonato Joseph A JA Brown J Mark JM Lusis Aldons J AJ Hazen Stanley L SL
Cell 20160310 1
Normal platelet function is critical to blood hemostasis and maintenance of a closed circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic diseases and enhanced potential for thrombotic events. We now show gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential. Plasma TMAO levels in subjects (n > 4,000) independently predicted incident (3 years) thrombosis (hear ...[more]