Molecular chaperones, ?-synuclein, and neurodegeneration.
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ABSTRACT:
SUBMITTER: Witt SN
PROVIDER: S-EPMC3537861 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Molecular chaperones, α-synuclein, and neurodegeneration.
Molecular neurobiology 20120825 2
Parkinson's disease (PD) is a devastating neurological condition that affects about 1 % of people older than 65 years of age. In PD, dopaminergic neurons in the mid-brain slowly accumulate cytoplasmic inclusions (Lewy bodies, LBs) of the protein alpha-synuclein (α-syn) and then gradually lose function and die off. Cell death is thought to be causally linked to the aggregation/fibrillization of α-syn. This review focuses on new findings about the structure of α-syn, about how α-syn cooperates wit ...[more]
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