Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Hormazabal P
PROVIDER: S-EPMC6356706 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Gonzalez-Hormazabal Patricio P Musleh Maher M Bustamante Marco M Stambuk Juan J Pisano Raul R Valladares Hector H Lanzarini Enrique E Chiong Hector H Rojas Jorge J Suazo Jose J Castro V Gonzalo VG Jara Lilian L Berger Zoltan Z
Genes 20181228 1
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers mainly by somatic mutations. This study aimed to assess if polymorphisms of the RAS/RAF/MEK/ERK pathway are associated with gastric cancer. A case-control study of 242 gastric cancer patients and 242 controls was performed to assess the association of 27 single nucleotide polymorp ...[more]