Ontology highlight
ABSTRACT:
SUBMITTER: Ariosa AR
PROVIDER: S-EPMC3541965 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Ariosa Aileen R AR Duncan Stacy S SS Saraogi Ishu I Lu Xiaodong X Brown April A Phillips Gregory J GJ Shan Shu-Ou SO
Molecular biology of the cell 20121107 2
During cotranslational protein targeting by the signal recognition particle (SRP), information about signal sequence binding in the SRP's M domain must be effectively communicated to its GTPase domain to turn on its interaction with the SRP receptor (SR) and thus deliver the cargo proteins to the membrane. A universally conserved "fingerloop" lines the signal sequence-binding groove of SRP; the precise role of this fingerloop in protein targeting has remained elusive. In this study, we show that ...[more]