Ontology highlight
ABSTRACT:
SUBMITTER: Saraogi I
PROVIDER: S-EPMC4050729 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Saraogi Ishu I Akopian David D Shan Shu-Ou SO
The Journal of cell biology 20140601 5
Efficient and accurate protein localization is essential to cells and requires protein-targeting machineries to both effectively capture the cargo in the cytosol and productively unload the cargo at the membrane. To understand how these challenges are met, we followed the interaction of translating ribosomes during their targeting by the signal recognition particle (SRP) using a site-specific fluorescent probe in the nascent protein. We show that initial recruitment of SRP receptor (SR) selectiv ...[more]