Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3760334 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Zhang Xin X Rashid Rumana R Wang Kai K Shan Shu-ou SO
Science (New York, N.Y.) 20100501 5979
Proper protein localization is essential for all cells. However, the precise mechanism by which high fidelity is achieved is not well understood for any protein-targeting pathway. To address this fundamental question, we investigated the signal recognition particle (SRP) pathway in Escherichia coli, which delivers proteins to the bacterial inner membrane through recognition of signal sequences on cargo proteins. Fidelity was thought to arise from the inability of SRP to bind strongly to incorrec ...[more]