Apolipoprotein E and familial longevity.
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ABSTRACT:
SUBMITTER: Schupf N
PROVIDER: S-EPMC3545094 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Apolipoprotein E and familial longevity.
Schupf Nicole N Barral Sandra S Perls Thomas T Newman Anne A Christensen Kaare K Thyagarajan Bharat B Province Michael M Rossi Winifred K WK Mayeux Richard R
Neurobiology of aging 20121005 4
Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality, although inconsistently. Offspring from long-lived families and spouse controls were recruited at 3 sites in the United States and Denmark. We used generalized estimating equations to compare the likelihood of carrying risk alleles in offspring (n = 2307) and sp ...[more]
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