Exome sequencing of three cases of familial exceptional longevity.
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ABSTRACT:
SUBMITTER: Cash TP
PROVIDER: S-EPMC4326919 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Exome sequencing of three cases of familial exceptional longevity.
Cash Timothy P TP Pita Guillermo G Domínguez Orlando O Alonso Maria R MR Moreno Leticia T LT Borrás Consuelo C Rodríguez-Mañas Leocadio L Santiago Catalina C Garatachea Nuria N Lucia Alejandro A Lucia Alejandro A Avellana Juan A JA Viña Jose J González-Neira Anna A Serrano Manuel M
Aging cell 20140812 6
Exceptional longevity (EL) is a rare phenotype that can cluster in families, and co-segregation of genetic variation in these families may point to candidate genes that could contribute to extended lifespan. In this study, for the first time, we have sequenced a total of seven exomes from exceptionally long-lived siblings (probands ≥ 103 years and at least one sibling ≥ 97 years) that come from three separate families. We have focused on rare functional variants (RFVs) which have ≤ 1% minor alle ...[more]
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