Ontology highlight
ABSTRACT:
SUBMITTER: De G
PROVIDER: S-EPMC3546113 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
De Gourab G Yip Wai-Ki WK Ionita-Laza Iuliana I Laird Nan N
PloS one 20130115 1
Genome-wide association studies have been able to identify disease associations with many common variants; however most of the estimated genetic contribution explained by these variants appears to be very modest. Rare variants are thought to have larger effect sizes compared to common SNPs but effects of rare variants cannot be tested in the GWAS setting. Here we propose a novel method to test for association of rare variants obtained by sequencing in family-based samples by collapsing the stand ...[more]