Ontology highlight
ABSTRACT:
SUBMITTER: Boname JM
PROVIDER: S-EPMC3551259 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Boname Jessica M JM Thomas Mair M Stagg Helen R HR Xu Ping P Peng Junmin J Lehner Paul J PJ
Traffic (Copenhagen, Denmark) 20091117 2
The downregulation of cell surface receptors by endocytosis is a fundamental requirement for the termination of signalling responses and ubiquitination is a critical regulatory step in receptor regulation. The K5 gene product of Kaposi's sarcoma-associated herpesvirus is an E3 ligase that ubiquitinates and downregulates several cell surface immunoreceptors, including major histocompatibility complex (MHC) class I molecules. Here, we show that K5 targets the membrane proximal lysine of MHC I for ...[more]