Ontology highlight
ABSTRACT:
SUBMITTER: Grice GL
PROVIDER: S-EPMC4533228 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Grice Guinevere L GL Lobb Ian T IT Weekes Michael P MP Gygi Steven P SP Antrobus Robin R Nathan James A JA
Cell reports 20150716 4
Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 polyubiquitin chains. Whether the proteasome also can bind atypical ubiquitin chains, including those linked by lysine-11, has not been well established. This is critically important, as lysine-11 polyubiquitination has been implicated in both proteasome-mediated degradation and non-degradative outcomes. Here we demonstrate that pure homotypic lysine-11-linked chains do not bind strongly to the mammalian pro ...[more]