Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhury I
PROVIDER: S-EPMC3711430 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Chaudhury Indrajit I Sareen Archana A Raghunandan Maya M Sobeck Alexandra A
Nucleic acids research 20130508 13
Fanconi Anemia (FA) and Bloom Syndrome share overlapping phenotypes including spontaneous chromosomal abnormalities and increased cancer predisposition. The FA protein pathway comprises an upstream core complex that mediates recruitment of two central players, FANCD2 and FANCI, to sites of stalled replication forks. Successful fork recovery depends on the Bloom's helicase BLM that participates in a larger protein complex ('BLMcx') containing topoisomerase III alpha, RMI1, RMI2 and replication pr ...[more]