Ontology highlight
ABSTRACT:
SUBMITTER: Lim LE
PROVIDER: S-EPMC3553693 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lim Leah E LE Vilchèze Catherine C Ng Carol C Jacobs William R WR Ramón-García Santiago S Thompson Charles J CJ
Antimicrobial agents and chemotherapy 20121119 2
Avermectins are a family of macrolides known for their anthelmintic activities and traditionally believed to be inactive against all bacteria. Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. Avermectins are approved for clinical and veterinary uses and have documented pharmacokinetic and safety profiles. We ...[more]