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Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains.

ABSTRACT: Avermectins are a family of macrolides known for their anthelmintic activities and traditionally believed to be inactive against all bacteria. Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. Avermectins are approved for clinical and veterinary uses and have documented pharmacokinetic and safety profiles. We suggest that avermectins could be repurposed for tuberculosis treatment.

SUBMITTER: Lim LE

PROVIDER: S-EPMC3553693 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains.

Lim Leah E LE Vilchèze Catherine C Ng Carol C Jacobs William R WR Ramón-García Santiago S Thompson Charles J CJ

Antimicrobial agents and chemotherapy 20121119 2

Avermectins are a family of macrolides known for their anthelmintic activities and traditionally believed to be inactive against all bacteria. Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. Avermectins are approved for clinical and veterinary uses and have documented pharmacokinetic and safety profiles. We ...[more]

PMID: 23165468

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