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Complete Genome Sequences of Two Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated in Guiyang, China.

ABSTRACT: We identified the genome sequences of two Mycobacterium tuberculosis isolates. They were resistant to rifampin and isoniazid, as determined by the agar proportion method, but were susceptible to isoniazid, as determined by the DNA array method. The genome sequences showed that a katG deletion led to the false diagnosis of isoniazid resistance by DNA array.

SUBMITTER: Chen Z

PROVIDER: S-EPMC5754478 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Complete Genome Sequences of Two Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated in Guiyang, China.

Chen Zhenghong Z Ou Weizheng W Fan Xiangyu X Cui Guzhen G Wang Qiong Q Li Qiang Q Sun Rong R Wu Xiaojuan X Qin Wan W Wang Yan Y

Genome announcements 20180104 1

We identified the genome sequences of two Mycobacterium tuberculosis isolates. They were resistant to rifampin and isoniazid, as determined by the agar proportion method, but were susceptible to isoniazid, as determined by the DNA array method. The genome sequences showed that a katG deletion led to the false diagnosis of isoniazid resistance by DNA array. ...[more]

PMID: 29301898

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