Ontology highlight
ABSTRACT:
SUBMITTER: Naveau M
PROVIDER: S-EPMC3553985 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Naveau Marie M Lazennec-Schurdevin Christine C Panvert Michel M Dubiez Etienne E Mechulam Yves Y Schmitt Emmanuelle E
Nucleic acids research 20121127 2
Heterotrimeric eukaryotic/archaeal translation initiation factor 2 (e/aIF2) binds initiator methionyl-tRNA and plays a key role in the selection of the start codon on messenger RNA. tRNA binding was extensively studied in the archaeal system. The γ subunit is able to bind tRNA, but the α subunit is required to reach high affinity whereas the β subunit has only a minor role. In Saccharomyces cerevisiae however, the available data suggest an opposite scenario with β having the most important contr ...[more]