Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC6208778 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Kim Eunah E Kim Joon Hyun JH Seo Keunhee K Hong Ka Young KY An Seon Woo A SWA Kwon Junyoung J Lee Seung-Jae V SV Jang Sung Key SK
Cellular and molecular life sciences : CMLS 20180717 23
The initiator tRNA (Met-tRNA <sub>i</sub> <sup>Met</sup> ) at the P site of the small ribosomal subunit plays an important role in the recognition of an mRNA start codon. In bacteria, the initiator tRNA carrier, IF2, facilitates the positioning of Met-tRNA <sub>i</sub> <sup>Met</sup> on the small ribosomal subunit. Eukarya contain the Met-tRNA <sub>i</sub> <sup>Met</sup> carrier, eIF2 (unrelated to IF2), whose carrier activity is inhibited under stress conditions by the phosphorylation of its α- ...[more]