Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC3554121 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Chen Xi X Müller Gerd A GA Quaas Marianne M Fischer Martin M Han Namshik N Stutchbury Benjamin B Sharrocks Andrew D AD Engeland Kurt K
Molecular and cellular biology 20121029 2
There are nearly 50 forkhead (FOX) transcription factors encoded in the human genome and, due to sharing a common DNA binding domain, they are all thought to bind to similar DNA sequences. It is therefore unclear how these transcription factors are targeted to specific chromatin regions to elicit specific biological effects. Here, we used chromatin immunoprecipitation followed by sequencing (ChIP-seq) to investigate the genome-wide chromatin binding mechanisms used by the forkhead transcription ...[more]