Ontology highlight
ABSTRACT:
SUBMITTER: Selimyan R
PROVIDER: S-EPMC3558432 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PLoS biology 20130129 1
Multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via V(D)J recombination. Here we provide a comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior to and during V(D)J recombination. DNA methylation did not correlate with the histone modification state on unrearranged alleles, indicating that these epigenetic marks were regulated independently. Instead, pockets of tissue-specific demethylation we ...[more]