Ontology highlight
ABSTRACT:
SUBMITTER: Wragg RT
PROVIDER: S-EPMC3559010 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Wragg Rachel T RT Snead David D Dong Yongming Y Ramlall Trudy F TF Menon Indu I Bai Jihong J Eliezer David D Dittman Jeremy S JS
Neuron 20130101 2
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing spontaneous fusion events, thus maintaining a high dynamic range in response to physiological stimuli. The presynaptic protein complexin can both promote and inhibit fusion through interactions between its α-helical domain and the SNARE complex. In addition, complexin's C-terminal half is required for the inhibition of spontaneous fusion in worm, fly, and mouse, although the molecular mechanism remains unexplained ...[more]