Ontology highlight
ABSTRACT:
SUBMITTER: Pendergrass SA
PROVIDER: S-EPMC3561060 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pendergrass Sarah A SA Brown-Gentry Kristin K Dudek Scott S Frase Alex A Torstenson Eric S ES Goodloe Robert R Ambite Jose Luis JL Avery Christy L CL Buyske Steve S Bůžková Petra P Deelman Ewa E Fesinmeyer Megan D MD Haiman Christopher A CA Heiss Gerardo G Hindorff Lucia A LA Hsu Chu-Nan CN Jackson Rebecca D RD Kooperberg Charles C Le Marchand Loic L Lin Yi Y Matise Tara C TC Monroe Kristine R KR Moreland Larry L Park Sungshim L SL Reiner Alex A Wallace Robert R Wilkens Lynn R LR Crawford Dana C DC Ritchie Marylyn D MD
PLoS genetics 20130131 1
Using a phenome-wide association study (PheWAS) approach, we comprehensively tested genetic variants for association with phenotypes available for 70,061 study participants in the Population Architecture using Genomics and Epidemiology (PAGE) network. Our aim was to better characterize the genetic architecture of complex traits and identify novel pleiotropic relationships. This PheWAS drew on five population-based studies representing four major racial/ethnic groups (European Americans (EA), Afr ...[more]