Ontology highlight
ABSTRACT:
SUBMITTER: Pinto R
PROVIDER: S-EPMC3563308 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Pinto Rachel R Leotta Lisa L Shanahan Erin R ER West Nicholas P NP Leyh Thomas S TS Britton Warwick W Triccas James A JA
The Journal of infectious diseases 20121207 5
New therapies to control tuberculosis are urgently required because of the inability of the only available vaccine, BCG, to adequately protect against tuberculosis. Here we demonstrate that proteins of the Mycobacterium tuberculosis sulfate-assimilation pathway (SAP) represent major immunogenic targets of the bacillus, as defined by strong T-cell recognition by both mice and humans infected with M. tuberculosis. SAP proteins displayed increased expression when M. tuberculosis was resident within ...[more]