Ontology highlight
ABSTRACT:
SUBMITTER: Gouzy A
PROVIDER: S-EPMC3856356 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Gouzy Alexandre A Larrouy-Maumus Gérald G Wu Ting-Di TD Peixoto Antonio A Levillain Florence F Lugo-Villarino Geanncarlo G Guerquin-Kern Jean-Luc JL de Carvalho Luiz Pedro Sório LP Poquet Yannick Y Neyrolles Olivier O
Nature chemical biology 20130929 11
Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant with an inactive AnsP1 revealed that the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing that aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus. ...[more]