Ontology highlight
ABSTRACT:
SUBMITTER: Lee BH
PROVIDER: S-EPMC3563867 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lee Byron H BH Taylor Margaret G MG Robinet Peggy P Smith Jonathan D JD Schweitzer Jessica J Sehayek Ephraim E Falzarano Sara M SM Magi-Galluzzi Cristina C Klein Eric A EA Ting Angela H AH
Cancer research 20121211 3
Recent epidemiologic data show that low serum cholesterol level as well as statin use is associated with a decreased risk of developing aggressive or advanced prostate cancer, suggesting a role for cholesterol in aggressive prostate cancer development. Intracellular cholesterol promotes prostate cancer progression as a substrate for de novo androgen synthesis and through regulation of AKT signaling. By conducting next-generation sequencing-based DNA methylome analysis, we have discovered marked ...[more]