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Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women.

ABSTRACT: In women, cortical bone mass decreases significantly at menopause. By contrast, loss of trabecular bone begins in the third decade and accelerates after menopause.The aim of the study was to investigate the effects of estrogen on cortical and trabecular bone.The Kronos Early Estrogen Prevention Study is a double-blind, randomized, placebo-controlled trial of menopausal hormone treatment (MHT) in women, enrolled within 6-36 months of their final menstrual period.The study was conducted at the Mayo Clinic, Rochester, Minnesota.Subjects were treated with placebo (n = 31), or .45 mg/d conjugated equine estrogens (n = 20), or transdermal 50 ?g/d 17?-estradiol (n = 25) with pulsed micronized progesterone.Cortical and trabecular microarchitecture at the distal radius was assessed by high-resolution peripheral quantitative computed tomography.At the distal radius, cortical volumetric bone mineral density (vBMD) decreased, and cortical porosity increased in the placebo group; MHT prevented these changes. By contrast, MHT did not prevent decreases in trabecular microarchitecture at the radius. However, MHT prevented decreases in trabecular vBMD at the thoracic spine (assessed in a subset of subjects; n = 51). These results indicate that MHT prevents deterioration in radial cortical vBMD and porosity in recently menopausal women.The maintenance of cortical bone in response to estrogen likely has important clinical implications because cortical bone morphology plays an important role in bone strength. However, effects of MHT on trabecular bone at the radius differ from those at the thoracic spine. Underlying mechanisms for these site-specific effects of MHT on cortical vs trabecular bone require further investigation.

SUBMITTER: Farr JN

PROVIDER: S-EPMC3565106 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women.

Farr Joshua N JN Khosla Sundeep S Miyabara Yuko Y Miller Virginia M VM Kearns Ann E AE

The Journal of clinical endocrinology and metabolism 20130115 2

<h4>Context</h4>In women, cortical bone mass decreases significantly at menopause. By contrast, loss of trabecular bone begins in the third decade and accelerates after menopause.<h4>Objective</h4>The aim of the study was to investigate the effects of estrogen on cortical and trabecular bone.<h4>Design</h4>The Kronos Early Estrogen Prevention Study is a double-blind, randomized, placebo-controlled trial of menopausal hormone treatment (MHT) in women, enrolled within 6-36 months of their final me ...[more]

PMID: 23322818

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Dataset Information

Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women.

Publications

Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women.

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