Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity.
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ABSTRACT:
SUBMITTER: Breitbach AS
PROVIDER: S-EPMC3565574 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity.
Breitbach Anthony S AS Broderick Adam H AH Jewell Christopher M CM Gunasekaran Suvai S Lin Qi Q Lynn David M DM Blackwell Helen E HE
Chemical communications (Cambridge, England) 20100909 1
We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration. ...[more]
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