Ontology highlight
ABSTRACT:
SUBMITTER: Kao CF
PROVIDER: S-EPMC3566789 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Kao Chih-Fei CF Yu Hung-Hsiang HH He Yisheng Y Kao Jui-Chun JC Lee Tzumin T
Neuron 20120201 4
The anterodorsal projection neuron lineage of Drosophila melanogaster produces 40 neuronal types in a stereotypic order. Here we take advantage of this complete lineage sequence to examine the role of known temporal fating factors, including Chinmo and the Hb/Kr/Pdm/Cas transcriptional cascade, within this diverse central brain lineage. Kr mutation affects the temporal fate of the neuroblast (NB) itself, causing a single fate to be skipped, whereas Chinmo null only elicits fate transformation of ...[more]