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Neuronal cell fate diversification controlled by sub-temporal action of Kruppel.


ABSTRACT: During Drosophila embryonic nervous system development, neuroblasts express a programmed cascade of five temporal transcription factors that govern the identity of cells generated at different time-points. However, these five temporal genes fall short of accounting for the many distinct cell types generated in large lineages. Here, we find that the late temporal gene castor sub-divides its large window in neuroblast 5-6 by simultaneously activating two cell fate determination cascades and a sub-temporal regulatory program. The sub-temporal program acts both upon itself and upon the determination cascades to diversify the castor window. Surprisingly, the early temporal gene Kruppel acts as one of the sub-temporal genes within the late castor window. Intriguingly, while the temporal gene castor activates the two determination cascades and the sub-temporal program, spatial cues controlling cell fate in the latter part of the 5-6 lineage exclusively act upon the determination cascades.

SUBMITTER: Stratmann J 

PROVIDER: S-EPMC5065313 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Neuronal cell fate diversification controlled by sub-temporal action of <i>Kruppel</i>.

Stratmann Johannes J   Gabilondo Hugo H   Benito-Sipos Jonathan J   Thor Stefan S  

eLife 20161014


During <i>Drosophila</i> embryonic nervous system development, neuroblasts express a programmed cascade of five temporal transcription factors that govern the identity of cells generated at different time-points. However, these five temporal genes fall short of accounting for the many distinct cell types generated in large lineages. Here, we find that the late temporal gene <i>castor</i> sub-divides its large window in neuroblast 5-6 by simultaneously activating two cell fate determination casca  ...[more]

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