Ontology highlight
ABSTRACT:
SUBMITTER: Stratmann J
PROVIDER: S-EPMC5065313 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Stratmann Johannes J Gabilondo Hugo H Benito-Sipos Jonathan J Thor Stefan S
eLife 20161014
During <i>Drosophila</i> embryonic nervous system development, neuroblasts express a programmed cascade of five temporal transcription factors that govern the identity of cells generated at different time-points. However, these five temporal genes fall short of accounting for the many distinct cell types generated in large lineages. Here, we find that the late temporal gene <i>castor</i> sub-divides its large window in neuroblast 5-6 by simultaneously activating two cell fate determination casca ...[more]