Unknown

Dataset Information

0

Neuronal cell fate diversification controlled by sub-temporal action of Kruppel.


ABSTRACT: During Drosophila embryonic nervous system development, neuroblasts express a programmed cascade of five temporal transcription factors that govern the identity of cells generated at different time-points. However, these five temporal genes fall short of accounting for the many distinct cell types generated in large lineages. Here, we find that the late temporal gene castor sub-divides its large window in neuroblast 5-6 by simultaneously activating two cell fate determination cascades and a sub-temporal regulatory program. The sub-temporal program acts both upon itself and upon the determination cascades to diversify the castor window. Surprisingly, the early temporal gene Kruppel acts as one of the sub-temporal genes within the late castor window. Intriguingly, while the temporal gene castor activates the two determination cascades and the sub-temporal program, spatial cues controlling cell fate in the latter part of the 5-6 lineage exclusively act upon the determination cascades.

SUBMITTER: Stratmann J 

PROVIDER: S-EPMC5065313 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neuronal cell fate diversification controlled by sub-temporal action of <i>Kruppel</i>.

Stratmann Johannes J   Gabilondo Hugo H   Benito-Sipos Jonathan J   Thor Stefan S  

eLife 20161014


During <i>Drosophila</i> embryonic nervous system development, neuroblasts express a programmed cascade of five temporal transcription factors that govern the identity of cells generated at different time-points. However, these five temporal genes fall short of accounting for the many distinct cell types generated in large lineages. Here, we find that the late temporal gene <i>castor</i> sub-divides its large window in neuroblast 5-6 by simultaneously activating two cell fate determination casca  ...[more]

Similar Datasets

| S-EPMC6764822 | biostudies-literature
| S-EPMC7491489 | biostudies-literature
2024-02-08 | PXD036442 | Pride
| S-EPMC8072034 | biostudies-literature
| S-EPMC5411104 | biostudies-literature
| S-EPMC3545287 | biostudies-literature
| S-EPMC3737729 | biostudies-literature
| S-EPMC2723065 | biostudies-literature
| S-EPMC6082428 | biostudies-literature
| S-EPMC3021026 | biostudies-literature