Ontology highlight
ABSTRACT:
SUBMITTER: Brohawn SG
PROVIDER: S-EPMC3568379 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Brohawn Stephen G SG Campbell Ernest B EB MacKinnon Roderick R
Proceedings of the National Academy of Sciences of the United States of America 20130122 6
TRAAK (TWIK-related arachidonic acid-stimulated K(+) channel, K2P4.1) K(+) ion channels are expressed predominantly in the nervous system to control cellular resting membrane potential and are regulated by mechanical and chemical properties of the lipid membrane. TRAAK channels are twofold symmetric, which precludes a direct extension of gating mechanisms that close canonical fourfold symmetric K(+) channels. We present the crystal structure of human TRAAK in complex with antibody antigen-bindin ...[more]