Dataset Information

A heme-binding domain in a voltage gated porassium channel

ABSTRACT: Heme-affinity pull-down assays and proteomics of lysates from primary cortical neurons identified and EAG channel, hERG3 (Kv11.3) binds to heme.

INSTRUMENT(S): Waters instrument model

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Cerebral Cortical Neuronï¿½

SUBMITTER: Rebekah Jukes-Jones

LAB HEAD: Emma Raven

PROVIDER: PXD019887 | Pride | 2020-09-17

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	TC080907001F002836.mzid.gz	Mzid
	TC080907001F002836.mzid_TC080907001_F002836.MGF	Mzid
	TC080907002F002837.mzid.gz	Mzid
	TC080907002F002837.mzid_TC080907002_F002837.MGF	Mzid
	TC080907003F002838.mzid.gz	Mzid

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Publications

Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.

Burton Mark J MJ Cresser-Brown Joel J Thomas Morgan M Portolano Nicola N Basran Jaswir J Freeman Samuel L SL Kwon Hanna H Bottrill Andrew R AR Llansola-Portoles Manuel J MJ Pascal Andrew A AA Jukes-Jones Rebekah R Chernova Tatyana T Schmid Ralf R Davies Noel W NW Storey Nina M NM Dorlet Pierre P Moody Peter C E PCE Mitcheson John S JS Raven Emma L EL

The Journal of biological chemistry 20200728 38

The EAG (<i>ether-à-go-go</i>) family of voltage-gated K<sup>+</sup> channels are important regulators of neuronal and cardiac action potential firing (excitability) and have major roles in human diseases such as epilepsy, schizophrenia, cancer, and sudden cardiac death. A defining feature of EAG (Kv10-12) channels is a highly conserved domain on the N terminus, known as the eag domain, consisting of a Per-ARNT-Sim (PAS) domain capped by a short sequence containing an amphipathic helix (Cap doma ...[more]

PMID: 32723862

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