Ontology highlight
ABSTRACT:
SUBMITTER: Morrison G
PROVIDER: S-EPMC3571105 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Physical review letters 20110329 13
We establish a framework for assessing whether the transition state location of a biopolymer, which can be inferred from single molecule pulling experiments, corresponds to the ensemble of structures that have equal probability of reaching either the folded or unfolded states (P(fold)=0.5). Using results for the forced unfolding of a RNA hairpin, an exactly soluble model, and an analytic theory, we show that P(fold) is solely determined by s, an experimentally measurable molecular tensegrity par ...[more]