No evidence of xenotropic murine leukemia virus-related virus transmission by blood transfusion from infected rhesus macaques.

ABSTRACT: The discovery of xenotropic murine leukemia virus-related virus (XMRV) in human tissue samples has been shown to be due to virus contamination with a recombinant murine retrovirus. However, due to the unknown pathogenicity of this novel retrovirus and its broad host range, including human cell lines, it is important to understand the modes of virus transmission and develop mitigation and management strategies to reduce the risk of human exposure and infection. XMRV transmission was evaluated by whole-blood transfusion in rhesus macaques. Monkeys were infected with XMRV to serve as donor monkeys for blood transfers at weeks 1, 2, and 3 into naïve animals. The donor and recipient monkeys were evaluated for XMRV infection by nested PCR assays with nucleotide sequence confirmation, Western blo

SUBMITTER: Williams DK 

PROVIDER: S-EPMC3571456 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature