Ontology highlight
ABSTRACT:
SUBMITTER: Silhar P
PROVIDER: S-EPMC3574188 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20121220 5
Botulinum neurotoxins (BoNTs) are the most lethal biotoxins known to mankind and are responsible for the neuroparalytic disease botulism. Current treatments for botulinum poisoning are all protein based and thus have a limited window of treatment opportunity. Inhibition of the BoNT light chain protease (LC) has emerged as a therapeutic strategy for the treatment of botulism as it may provide an effective post exposure remedy. Using a combination of crystallographic and modeling studies a series ...[more]