Ontology highlight
ABSTRACT:
SUBMITTER: Janda CY
PROVIDER: S-EPMC3577348 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Janda Claudia Y CY Waghray Deepa D Levin Aron M AM Thomas Christoph C Garcia K Christopher KC
Science (New York, N.Y.) 20120531 6090
Wnts are lipid-modified morphogens that play critical roles in development principally through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8 (XWnt8) in complex with mouse Frizzled-8 (Fz8) cysteine-rich domain (CRD) reveals an unusual two-domain Wnt structure, not obviously related to known protein folds, resembling a "hand" with "thumb" and "index" fingers extended to grasp the Fz8-CRD at two distinct binding sites. One site is dominated by a palmitoleic acid lipi ...[more]