Dataset Information
Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-?-allyl-Pd cyclization cascade reaction.
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ABSTRACT:
SUBMITTER: Lux MC
PROVIDER: S-EPMC6601619 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction.
Chemical communications (Cambridge, England) 20190531 49
Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords a variety of bicyclic ether sca ...[more]