Ontology highlight
ABSTRACT:
SUBMITTER: Sena LA
PROVIDER: S-EPMC3582741 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Sena Laura A LA Li Sha S Jairaman Amit A Prakriya Murali M Ezponda Teresa T Hildeman David A DA Wang Chyung-Ru CR Schumacker Paul T PT Licht Jonathan D JD Perlman Harris H Bryce Paul J PJ Chandel Navdeep S NS
Immunity 20130215 2
It is widely appreciated that T cells increase glycolytic flux during activation, but the role of mitochondrial flux is unclear. Here, we have shown that mitochondrial metabolism in the absence of glucose metabolism is sufficient to support interleukin-2 (IL-2) induction. Furthermore, we used mice with reduced mitochondrial reactive oxygen species (mROS) production in T cells (T-Uqcrfs(-/-) mice) to show that mitochondria are required for T cell activation to produce mROS for activation of nucle ...[more]