Ontology highlight
ABSTRACT:
SUBMITTER: Stevanovic A
PROVIDER: S-EPMC3588876 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Stevanovic Ana A Thiele Christoph C
Journal of lipid research 20121129 2
Ancient ubiquitous protein 1 (AUP1) is a multifunctional protein, which acts on both lipid droplets (LDs) and the endoplasmic reticulum (ER) membrane. Double localization to these two organelles, featuring very different membrane characteristics, was observed also for several other integral proteins, but little is known about the signals and mechanisms behind dual protein targeting to ER and LDs. Here we dissect the AUP1 targeting signals by analyses of localization and topology of several delet ...[more]