Ontology highlight
ABSTRACT:
SUBMITTER: Lohmann D
PROVIDER: S-EPMC3764060 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lohmann Daniel D Spandl Johanna J Stevanovic Ana A Schoene Mario M Philippou-Massier Julia J Thiele Christoph C
PloS one 20130905 9
Lipid droplets, the intracellular storage organelles for neutral lipids, exist in a wide range of sizes and of morphologically distinct organization, from loosely dispersed lipid droplets to tightly packed lipid droplet clusters. We show that the lipid droplet protein AUP1 induces cluster formation. A fraction of AUP1 is monoubiquitinated at various lysine residues. This process depends on its internal CUE domain, which is a known ubiquitin-binding domain. AUP1 with a deleted or point mutagenize ...[more]