Ontology highlight
ABSTRACT:
SUBMITTER: Sikora M
PROVIDER: S-EPMC3592873 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sikora Mateusz M Cieplak Marek M
PloS one 20130308 3
We consider mechanical stability of dimeric and monomeric proteins with the cystine knot motif. A structure based dynamical model is used to demonstrate that all dimeric and some monomeric proteins of this kind should have considerable resistance to stretching that is significantly larger than that of titin. The mechanisms of the large mechanostability are elucidated. In most cases, it originates from the induced formation of one or two cystine slipknots. Since there are four termini in a dimer, ...[more]