Ontology highlight
ABSTRACT:
SUBMITTER: Fu S
PROVIDER: S-EPMC3593102 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Fu Shibo S Rivera Michael M Ko Eric C EC Sikora Andrew G AG Chen Chien-Ting CT Vu Ha Linh HL Cannan David D Eisenstein Samuel S Rosenstein Barry S BS Aguirre-Ghiso Julio J Chen Shu-Hsia SH Kao Johnny J
Journal of cell science & therapy 20111001 2
Targeting epidermal growth factor receptor (EGFR) is a promising approach to increasing radiosensitivity of head and neck cancers but treatment resistance remains an important clinical problem. We hypothesize that combined EGFR and cyclooxygenase-2 (COX-2) inhibition, using small molecule inhibitors erlotinib and celecoxib, respectively would further increase the antitumor activity of radiotherapy. The effects of combinations of celecoxib, erlotinib and ionizing radiation (IR) on cell growth, ce ...[more]