Ontology highlight
ABSTRACT:
SUBMITTER: Wang YM
PROVIDER: S-EPMC3593589 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wang Yue-Ming YM Ong Su Sien SS Chai Sergio C SC Chen Taosheng T
Expert opinion on drug metabolism & toxicology 20120503 7
<h4>Introduction</h4>The xenobiotic detoxification system, which protects the human body from external chemicals, comprises drug-metabolizing enzymes and transporters whose expressions are regulated by pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). The progress made in a large number of recent studies calls for a timely review to summarize and highlight these key discoveries.<h4>Areas covered</h4>This review summarizes recent advances in elucidating the roles of PXR an ...[more]