Ontology highlight
ABSTRACT:
SUBMITTER: Forrester HB
PROVIDER: S-EPMC3595223 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130312 3
Dupuytren's disease (DD) is a classic example of pathological fibrosis which results in a debilitating disorder affecting a large sector of the human population. It is characterized by excessive local proliferation of fibroblasts and over-production of collagen and other components of extracellular matrix (ECM) in the palmar fascia. The fibrosis progressively results in contracture of elements between the palmar fascia and skin causing flexion deformity or clawing of the fingers and a severe red ...[more]