Dataset Information

Role of mTOR in regulating the extra cellular matrix

ABSTRACT: Explored the potential role of mTOR in regulating the extra cellular matrix of TGF-b1-stimulated IPF fibroblasts grown under macromolecular crowding conditions in the presence of either CZ415 or rapamycin

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Fibroblast Of Lung

SUBMITTER: Maria Faelth Savitski

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD010164 | Pride | 2018-11-04

REPOSITORIES: Pride

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			Action	DRS
	00867_F1_R1_P0102539B01_TMT10.raw.gz	Raw
	00867_F1_R1_P0102539B02_TMT10.raw.gz	Raw
	00867_F1_R1_P0102539B03_TMT10.raw.gz	Raw
	00867_F1_R1_P0102539B04_TMT10.raw.gz	Raw
	00867_F1_R1_P0102539B05_TMT10.raw.gz	Raw

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Publications

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.

Woodcock Hannah V HV Eley Jessica D JD Guillotin Delphine D Platé Manuela M Nanthakumar Carmel B CB Martufi Matteo M Peace Simon S Joberty Gerard G Poeckel Daniel D Good Robert B RB Taylor Adam R AR Zinn Nico N Redding Matthew M Forty Ellen J EJ Hynds Robert E RE Swanton Charles C Karsdal Morten M Maher Toby M TM Fisher Andrew A Bergamini Giovanna G Marshall Richard P RP Blanchard Andy D AD Mercer Paul F PF Chambers Rachel C RC

Nature communications 20190102 1

Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR inhibition currently under clinical evaluation in IPF. Here we demonstrate that rapamycin-insensitive mTORC1 signaling via 4E-BP1 is a critical pathway for TGF-β<sub>1</sub> stimulated collagen synthesis in human lung fibroblasts, whereas canoni ...[more]

PMID: 30602778

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