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The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

ABSTRACT: The identification of potent spliceosome modulators that demonstrate antitumor activity indicates that this complex may be a target for drug development. Several natural products have been demonstrated to bind to the SF3b1 subunit of this macromolecule and these agents modulate alternative RNA splicing. In this article we describe their biological properties, discuss the validity of the spliceosome as a therapeutic target, and propose that alteration of alternative splicing represents a viable approach for inducing tumor-selective cytotoxicity.

SUBMITTER: Webb TR

PROVIDER: S-EPMC3596818 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

Webb Thomas R TR Joyner Amanda S AS Potter Philip M PM

Drug discovery today 20120803 1-2

The identification of potent spliceosome modulators that demonstrate antitumor activity indicates that this complex may be a target for drug development. Several natural products have been demonstrated to bind to the SF3b1 subunit of this macromolecule and these agents modulate alternative RNA splicing. In this article we describe their biological properties, discuss the validity of the spliceosome as a therapeutic target, and propose that alteration of alternative splicing represents a viable a ...[more]

PMID: 22885522

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